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Skin Moisturizing Antioxidant Active Ingredient Squalene

Cosmate®SQE Squalene, is an olefin found in many foods in daily life. Among them, shark liver oil has a higher content, accounting for an average of over 40% of the total shark glycerol content. A few plant oils, such as olive oil, wild jasmine seed oil, and rice bran oil, also have a higher content of squalene; Cosmate®SQE Squalene is a colorless oily liquid with a special odor, insoluble in water, active in nature, and easily oxidized. It is also such a substance that is widely used in fields such as food, cosmetics, and health products due to its good biological activity and safety.

Cosmate®SQE Squalene was initially extracted from the liver of deep-sea sharks. In fact, squalene is not only present in shark liver, but also distributed in many plants, but its content is not high. Most of it is less than 5% of unsaponifiable substances in plant oil, and a few have a higher content. For example, the content of squalene in wild jasmine seed oil is higher, exceeding that in olive oil and rice bran oil. In addition, squalene is also widely distributed in our body's skin, subcutaneous fat, liver, nails, brain and other organs. It participates in cholesterol synthesis and various biological reactions in the body to promote metabolism and operation, and improve the body's resistance and defense capabilities; In other words, squalene is involved in body metabolism and cellular biochemical reactions in the body.

Squalene is a naturally occurring lipid found in human sebum, plants, and animals. It is a key component of the skin’s lipid barrier, playing a vital role in maintaining hydration and protecting against environmental stressors. Traditionally sourced from shark liver oil, modern production methods now focus on plant-based sources (e.g., olive oil, amaranth seed oil) and biotechnological processes to ensure sustainability and ethical standards. While squalene is highly effective in skincare, it is less stable than its hydrogenated form, squalane, due to its susceptibility to oxidation.

Squalene Key Functions

Deep Moisturization:Squalene acts as a natural emollient, helping to lock in moisture and improve skin elasticity.

Antioxidant Protection:Squalene neutralizes free radicals caused by UV radiation and pollution, reducing oxidative stress and premature aging.

Skin Barrier Reinforcement:Squalene strengthens the skin’s natural lipid barrier, enhancing its ability to retain moisture and defend against irritants.

Wound Healing and Regeneration:Squalene promotes skin repair and regeneration, making it ideal for damaged or aging skin.

Enhanced Absorption:Squalene facilitates the penetration of other active ingredients, improving their efficacy.

Squalene Mechanism of Action

Squalene works by integrating into the stratum corneum due to its molecular similarity to the skin’s natural lipids, filling gaps between skin cells and restoring smoothness. It forms a breathable, protective layer that locks in moisture while allowing the skin to breathe. Additionally, squalene acts as an antioxidant, scavenging free radicals and reactive oxygen species (ROS) to prevent cellular damage and oxidative stress. It also enhances the penetration and effectiveness of other active ingredients, such as vitamins and retinoids, through synergistic delivery.

Squanlene benefits and Advantages

Biocompatibility:Naturally present in human sebum, making it highly compatible with all skin types, including sensitive skin.

Versatility:Suitable for a wide range of skincare products, including moisturizers, serums, sunscreens, and cleansers.

Anti-Aging Benefits:Improves skin elasticity, reduces fine lines, and promotes a youthful appearance.

Sustainability:Plant-derived and biotech-produced squalene are eco-friendly and align with vegan and cruelty-free trends.

Synergy with Actives:Enhances the performance of other bioactive ingredients while reducing potential irritation.

Technical Parameters: 1. Cosmate®SQE Squalene Soybean oil extraction Source

Appearance

Light yellow to colorless transparent liquid

Odor

Mid characteristic

Total Squalene Content

≥70.0%

Iodine Value

280~330g/100g

Acidity

≤1.0ml

2. Cosmate®SQE Squalene Shark liver oil extraction Source

Appearance

Light yellow to colorless transparent liquid

Odor

Characteristic

Density @20℃  (g/ml)

0.845-0.865

Refractive Index @20℃

1.4945-1.4980

Acid Value   (mg KOH/g)

≤1

Iodine Value   (gl2/100g)

360-400

Saponification Value   (mg KOH/g)

≤1

Peroxide Value   (meq/kg)

≤5

Gas Chromatography    (%)

≥99

Arsenic   (ppm)

≤0.1

Cadmium   (ppm)

≤0.1

Lead    (ppm)

≤0.1

Mercury   (ppm)

≤0.1

Dioxins + DL PCB’S (pg(WHO TEQ/g)

≤6.0

Dioxins (pg(WHO TEQ/g)

≤1.75

NDLPCB’S (ng/g)

≤200

PAH's (benzo(a)pyrene) (μg/kg)

≤2

Total PAH's (μg/kg)

≤10

E. Coli & Salmonella

Negative

Coliforms and S.aureus

Negative

Applications: * Moisturizing and antioxidant, promoting skin health; * Oxygen carrying/hypoxia resistant, squalene is a widely used functional ingredient in hypoxia resistant health food; * Medical delivery carriers/vaccine adjuvants.

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