Cosmate®EGT,Ergothioneine(EGT) is an important active substance in human boday.Ergothioneine is obtained by multi fermentation of Hericium Erinaceum & Tricholoma Matsutake.Multi fermentation can increase the yield of L-Ergothioneine,which is a sulfur-containing derivative of the amino acid histidine,a unique stable antioxidant and cytoprotective agent,existing in the human body.Ergothioneine can be transferred inside mitochondria by the transporter OCTN-1 in skin keratinocytes and fibroblasts,thus playing the anti-oxidation and protection functions.
Cosmate®EGT is a potent antioxidant and has proven to protect the skin against sun damage and other signs of aging. Cosmate®EGT protects cells from damage caused by ultraviolet rays. It reduces reactive oxygen species in the body and may help repair DNA damaged by ultraviolet rays. It also inhibits the apoptotic response of cells exposed to UVA rays, increasing their viability.Ergothioneine has a powerful cytoprotective effect. Cosmate®EGT anti-inflammatory and antioxidant properties used in sunscreen cosmetics. UVA in the sun can penetrate into the skin dermis and affect the growth of epidermal cells, making the skin surface cells aging earlier, and UVB is easy to lead to skin cancer. Ergothione was found to minimize the formation of reactive oxygen species and protect cells from radiation damage. It also stimulates collagen production in the skin and decreases inflammation. As one of the last organs to receive nutrients, it is essential to provide it with these nutrients in skincare products. At physiological concentrations, ergothioneine exhibits a potent controlled diffusional inactivation of hydroxyl radicals and prevents the generation of atomic oxygen, which protects erythrocytes from neutrophils from normally functioning or moribulently inflammatory sites. When combined with other antioxidants and skin care products, ergothioneine is effective in reducing the signs of aging and improving the overall appearance of the skin.
Ergothioneine (EGT) is a naturally occurring, unique sulfur-containing amino acid that possesses remarkable biological activities. It is found in various natural sources such as mushrooms, certain grains, and legumes.Ergothioneine has gained significant attention in the fields of cosmetics and personal care due to its excellent antioxidant and cytoprotective properties. It can be actively taken up by human cells and plays a crucial role in maintaining cellular health and combating oxidative stress and inflammation.
Ergothioneine Key Functions
- Antioxidant Protection: Ergothioneine is a powerful antioxidant that can effectively scavenge free radicals generated by environmental factors like UV radiation and pollution. By doing so, Ergothioneine helps to prevent oxidative damage to skin cells, slows down the degradation of collagen and elastin fibers, and thus delays the appearance of wrinkles and fine lines, keeping the skin looking youthful and firm.
- Anti-inflammatory Effects: Ergothioneine has strong anti-inflammatory capabilities. Ergothioneine can reduce skin redness, swelling, and irritation caused by various factors such as acne, allergies, and contact dermatitis. Ergothioneine soothes the skin and helps to alleviate itching and discomfort, making it especially beneficial for sensitive and reactive skin types.
- Skin Hydration and Barrier Function: Ergothioneine can enhance the skin's natural moisture retention capacity by improving the function of the skin's barrier. It helps to lock in moisture, making the skin feel more hydrated, smooth, and supple. This also strengthens the skin's resistance to external harmful substances and environmental stressors.
- Hair Health Maintenance: In haircare products, Ergothioneine plays a role in protecting the hair follicles from oxidative damage. It helps to prevent hair breakage, improve hair elasticity and shine, and promote healthy hair growth. Ergothioneine is particularly effective in treating damaged hair caused by heat styling, chemical treatments, and environmental pollution.
Ergothioneine Mechanism of Action
- Free Radical Scavenging: The unique molecular structure of Ergothioneine enables it to directly react with free radicals, donating electrons to neutralize them and terminate the chain reactions of oxidative damage. Its thiol group is particularly important in this process, as it can readily interact with reactive oxygen species and other free radicals.
- Modulation of Inflammatory Signaling Pathways: Ergothioneine can interfere with the activation of certain inflammatory signaling pathways in cells. It inhibits the production and release of pro-inflammatory cytokines and mediators, such as TNF-α, IL-6, and COX-2, thereby reducing the inflammatory response at the cellular level.
- Metal Chelation: Ergothioneine has the ability to chelate metal ions, especially copper and iron. By binding to these metal ions, it prevents them from participating in Fenton reactions and other redox processes that can generate harmful free radicals, thus reducing oxidative stress.
- Enhancement of Cellular Defense Systems: Ergothioneine can upregulate the expression of certain antioxidant enzymes and proteins in cells, such as glutathione peroxidase and superoxide dismutase. This helps to boost the cell's own antioxidant defense system and improve its ability to resist oxidative damage.
Ergothioneine Advantages
- High Stability: Ergothioneine is relatively stable under a wide range of conditions, including different pH values and temperatures. This stability allows it to maintain its biological activity and efficacy in various cosmetic and personal care formulations, whether they are aqueous, oil-based, or emulsion systems.
- Excellent Biocompatibility: Ergothioneine is well-tolerated by the skin and has low toxicity and irritation potential.Ergothioneine is suitable for use in products for all skin types, including sensitive skin, without causing adverse reactions such as allergies or skin irritation.
- Versatile Compatibility: Ergothioneine can be easily combined with other active ingredients commonly used in cosmetics and personal care products, such as vitamins, plant extracts, and hyaluronic acid. It shows good synergy with these ingredients, enhancing the overall efficacy of the formulations.
- Sustainable Source: Ergothioneine can be produced through sustainable fermentation processes using microorganisms. This provides an environmentally friendly and renewable source of the ingredient, meeting the growing demand for sustainable and eco-friendly products in the beauty industry.
Which kind of product contains Ergothioneine
- Skincare Products
- Anti-aging Creams and Serums: Ergothioneine is often incorporated into anti-aging formulations to combat wrinkles, improve skin elasticity, and enhance skin firmness. It works in synergy with other anti-aging ingredients to provide comprehensive anti-aging effects.
- Sunscreens: Due to its antioxidant properties,Ergothioneine can be added to sunscreens to enhance their protection against UV-induced oxidative damage. Ergothioneine helps to prevent sunburn, DNA damage, and premature skin aging caused by sun exposure.
- Moisturizers and Face Masks: In moisturizers and face masks, Ergothioneine helps to improve skin hydration and maintain skin moisture levels. It makes the skin feel soft and supple, and can also help to reduce the appearance of fine lines caused by dryness.
- Acne and Blemish Treatments: The anti-inflammatory and antioxidant effects of Ergothioneine make it suitable for use in acne and blemish treatments. It can help to reduce inflammation, prevent bacterial growth, and promote the healing of acne lesions.
- Haircare Products
- Shampoos and Conditioners: Ergothioneine can be found in shampoos and conditioners to improve hair health. It helps to repair damaged hair, reduce frizz, and increase hair shine and manageability.
- Hair Masks and Treatments: In hair masks and deep conditioning treatments, Ergothioneine provides intensive nourishment and protection to the hair. It penetrates the hair shaft to strengthen the hair from within and improve its overall quality.
- Scalp Serums: For scalp care, Ergothioneine-containing serums can help to soothe the scalp, reduce dandruff and itching, and promote a healthy scalp environment for optimal hair growth.
- Body Care Products
- Body Lotions and Creams: Ergothioneine can be added to body lotions and creams to moisturize and protect the skin. It helps to improve the skin's texture, making it smoother and more radiant.
- Hand Sanitizers and Soaps: In hand sanitizers and soaps, Ergothioneine can provide antioxidant and anti-inflammatory benefits, helping to prevent skin dryness and irritation caused by frequent hand washing.
Technical Parameters:
Appearance |
White Powder |
Assay |
99% min. |
Loss on Drying |
1% max. |
Heavy Metals |
10 ppm max. |
Arsenic |
2 ppm max. |
Lead |
2 ppm max. |
Mercury |
1 ppm max. |
E.Coli |
Negative |
Total Plate Count |
1,000cfu/g |
Yeast & Mold |
100 cfu/g |
Applications:
*Anti-Aging
*Antioxidation
*Sun Screen
*Skin Reparing