Berberine hydrochloride, an active ingredient with antimicrobial, anti-inflammatory and antioxidant properties

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Extracted from medicinal plants like Coptis chinensis and Phellodendron amurense, berberine hydrochloride is a stable, water-soluble hydrochloride salt of berberine. In cosmetics, it stands out as a natural alternative to synthetic preservatives and anti-acne agents, leveraging its centuries-old use in traditional medicine and modern scientific validation. Its yellow crystalline form integrates seamlessly into various formulations—from serums to creams—without compromising stability. Unlike harsh chemicals, it works gently to balance skin microflora, calm inflammation, and combat blemishes, making it suitable for sensitive, acne-prone, and oily skin types. Its multifunctional nature reduces the need for multiple additives, simplifying formulations while boosting efficacy. Key Functions of Berberine Hydrochloride Antimicrobial Activity: Inhibits acne-causing bacteria (Propionibacterium acnes, Staphylococcus aureus) and fungi linked to dandruff. Anti-Inflammatory Action: Reduces redness, swelling, and irritation caused by clogged pores or environmental stressors. Sebum Regulation: Controls excessive oil production, preventing clogged pores and shine. Antioxidant Protection: Neutralizes free radicals to defend against oxidative damage and premature aging. Skin Barrier Support: Strengthens the skin’s natural defense layer by balancing microbial diversity. Mechanism of Action of Berberine Hydrochloride Antimicrobial: Disrupts the cell membranes of harmful microbes, inhibiting their growth and replication to prevent breakouts and infections. Anti-Inflammatory: Blocks pro-inflammatory cytokines (e.g., TNF-α, IL-6) and suppresses NF-κB signaling, reducing redness and swelling at the source. Sebum Regulation: Targets sebocytes (oil-producing cells) to inhibit lipid synthesis, balancing sebum levels without over-drying the skin. Antioxidant: Scavenges reactive oxygen species (ROS) and enhances the activity of endogenous antioxidants (e.g., superoxide dismutase), protecting skin cells from oxidative stress. Benefits and Advantages of Berberine Hydrochloride Natural & Gentle: Derived from plants, it minimizes irritation, making it safe for sensitive and acne-prone skin. Multi-Tasking: Combines anti-acne, soothing, and antioxidant benefits, streamlining formulations. Stability: Water-soluble and heat-resistant, it maintains efficacy in various pH ranges and storage conditions. Microbiome-Friendly: Inhibits harmful bacteria while preserving beneficial skin flora, supporting long-term skin health. Regulatory Compliance: Meets global cosmetic standards, ensuring compatibility with clean beauty trends. Key Technical Parameters

Item	Specification
Appearance	Yellow crystalline powder, odorless
Identification	Positive (by HPLC and UV spectroscopy)
Assay (on dry basis)	≥97.0%
Loss on Drying	≤10.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤10 ppm
Related Substances	Other alkaloids ≤2.0%
Microbial Count	Total Aerobic Microbes ≤1000 CFU/g
	Yeast & Mold ≤100 CFU/g

Applications: Acne Treatments: Gels, spot treatments, and serums to clear pimples and prevent recurrence. Soothe & Repair Products: Calming creams, masks, and toners for red, irritated, or post-treatment skin. Oil-Control Formulations: Mattifying primers, cleansers, and moisturizers for oily/combination skin. Anti-Aging Skincare: Serums and creams to protect against free radicals and maintain a youthful glow. Scalp Care: Shampoos and treatments to combat dandruff and folliculitis by targeting microbial overgrowth.

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Berberine hydrochloride

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Berberine hydrochloride, an active ingredient with antimicrobial, anti-inflammatory and antioxidant properties

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